General description of Microzide Microzide is a medication commonly prescribed for high blood pressure, also known as hypertension. It contains the active ingredient hydrochlorothiazide, which is a diuretic that works by increasing urination to help remove excess fluid from the body. Hydrochlorothiazide is also used to treat fluid retention (edema). Hydrochlorothiazide is a thiazide diuretic that acts on the kidneys to increase the production of urine. This helps to lower blood pressure by reducing the volume of fluid in the body. By removing excess fluid, hydrochlorothiazide helps to relieve the strain on the heart and blood vessels, making it an …